OFFICE HOMESUPPLYSignature M650 gives shoppers a choice of body sizes rather than a single universal shape. Logitech recommends the regular model for small to medium hands, M650 L for larger hands, and M650 L LEFT for left-handed use. SmartWheel switches between precise line scrolling and faster scrolling, while Bluetooth Low Energy or a Logi Bolt receiver provides the connection. This family is a practical alternative to premium workflow mice when hand sizing is the priority. Select the handedness and size explicitly: the variants are not interchangeable. Optional software features also need their own operating-system compatibility check.
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Everyday mouse use when body size, handedness, and flexible connection options matter.
Our assessment is based on documented specifications and sources. Hands-on testing is not implied.
Know the details
| Connection | Bluetooth Low Energy or Logi Bolt USB receiver |
|---|---|
| Sizes | Regular, large, large left-handed |
| Scroll | SmartWheel |
| Product identity | Logitech Signature M650 Wireless Mouse |
| Manufacturer-described format | Contoured wireless mouse family with size options and SmartWheel scrolling. |
| Model | Signature M650 |
| Manufacturer part | 910-006268 |
| Variant | Black, small/medium, right-handed |
Information reviewed 2026-10-10. Confirm the current configuration, dimensions and compatibility before purchasing.
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